Preparation and properties of Pue-loaded HA-ADH-PS nanomicelles

Puerarin (Pue) is the most abundant isoflavonoid in kudzu root.It has been widely used as a therapeutic agent for the treatment of cardiovascular diseases.However, poor-bioavailability of puerarin is the main obstacle to its widespread clinical applications.In this paper, HA-ADH-PS nanomicelles were prepared by chemical modification, noncovalent mo

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Language Assessment in Multilingualism and Awake Neurosurgery

Multilingualism has become a worldwide phenomenon that poses critical issues about the language assessment in patients undergoing awake neurosurgery in eloquent brain areas.The accuracy and sensitivity of multilingual perioperative language assessment procedures is crucial for a number of reasons: they should be appropriate to detect deficits in ea

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Prognostic impact of reduced HER2 protein expression in post-neoadjuvant therapy resection specimens: A single institution experience and review of the literature

Background: Retesting for Human epidermal growth factor receptor-2 (HER2) in post-neoadjuvant therapy resection is variable, and data is conflicting regarding the prognostic significance of changes in HER2 expression pre and post therapy.Methods: We identified 104 patients with localized HER2 IHC 3+ breast cancer who received neoadjuvant trastuzuma

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